Semen Sperm

12May/09Off

Semen Sperm

Overcome Infertilty 48 --What is Sperm-Ubiquitin tag immunoassay (SUTI)??

As we mentioned in previous articles, infertility is defined as inability of a couple to conceive after 12 months of unprotected sexual intercourse or can not carry the pregnancy to term. It effects over 5 millions couple alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seeks help from professional specialist.In this article, we will discuss what is male infertility sperm-ubiquitin tag immunoassay (SUTI)??

I. Definition
The test is to detect the inherited fertility disorder of the infertile male to avoid any unnecessary
fertility treatments for women.

II. Procedure
The semen sperm is taken from the infertile male in the clinic laboratory and the surface of sperm is screened for ubiquintin which is a small, highly-conserved regulatory protein that is ubiquitously expressed in complex structures enclosed within membranes.

III. Diagnosis
Since ubiquitnin is considered a universal marker of semen abnormalities, including sperm head and tail defects and semen contaminants such as spermatids, leukocytes and cellular debris.
The semen example is screened through immunofluorescence and flow cytometry, if there is an displays of increasing binding of anti-ubiquitin antibodies to sperm surface, the sample sperm is considered abnormality which increases the risk of infertility becasues elevated sperm ubiquitin levels have been associated with reduced fertility or infertility.

This test is still in developed state, if proven success, it not only helps to avoid many unnecessary treatments for unfertile couple but also helps to remove damaged sperm from semen sample before IVF and ICSC.

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