Antihistamine Loratidine
Antihistamine Loratidine
Chemistry Challenge?
1. That O2 is paramagnetic can be explained
a) by the Lewis structure of O2
b) by resonance
c) as a violation of the octet rule
d) by the molecular orbital diagram for O2
e) by hybridization of atomic orbitals in O2
2. Loratidine is the active ingredient in the antihistamine known Claritin. Mass spectral analysis of loratidine shows M+ at m/z = 382 and M+ at m/z = 384 in an approximate ratio of 3:1 in intensity. The mass spectral data indicates that loratidine contains
a) fluorine b) chlorine c) bromine d) iodine e) phosphorus
Thanks for your explanation.
For Q2, loratidine is known to contain nitrogen. Can you tell me what is the minimum no. of nitrogen atoms in loratidine?
1. d)oxygen
The unpaired electrons spin in the same direction as each other increasing the magnetic field.
2. b)chlorine The natural abundance of the isotopes of chlorine (35Cl and 37Cl) are around 75% and 25%, respectively. Because of this, the molecular ion and M+2 peaks are in a 3:1 ratio on a mass spec.
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